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Angelina Cask Neurological Research Foundation is a Not For Profit Charity, helping to facilitate finding a cure for the Cask Gene Mutation to help those diagnosed with CASK. Please register your interest in supporting us. By registering we will let you know of up and coming research projects and events you can participate in for the purpose of raising awareness and funds in finding a Cure.

Angelina Cask Neurological Research Foundation Ltd

“In some ways, that CASK-linked pathology is degenerative in nature provides a positive outlook. Because microcephaly in CASK-linked pathology progresses postnatally, there may be a temporal window when therapeutic intervention might prevent or slow further brain cell loss. Regression, even in adolescence, has also been observed in some cases of MICPCH [119], again offering the tantalizing possibility that a therapeutic approach might prevent such decline under conditions when degeneration is known to progressThe potential benefits of intervention might extend even further given that non-cell-autonomous toxicity could also affect functioning of the remaining neurons; reduction of such toxicity, especially when coupled with high-intensity rehabilitative measures [120], might offer real hope for a positive impact on functional outcomes.”